Potent Vasoconstrictor Kisspeptin‐10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist
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Potent Vasoconstrictor Kisspeptin‐10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist
BACKGROUND Kisspeptin-10 (KP-10), a potent vasoconstrictor and inhibitor of angiogenesis, and its receptor, GPR54, have currently received much attention in relation to pre-eclampsia. However, it still remains unknown whether KP-10 could affect atherogenesis. METHODS AND RESULTS We evaluated the effects of KP-10 on human umbilical vein endothelial cells, human monocyte-derived macrophages, hu...
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ژورنال
عنوان ژورنال: Journal of the American Heart Association
سال: 2017
ISSN: 2047-9980
DOI: 10.1161/jaha.117.005790